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The Research Blog
Peptide science, one system at a time.
Plain-language articles drawn from the Targeted Peptide Systems books: the reasoning behind protocols, the mistakes people make, and what the current research does and doesn’t show. Every article cites its sources and the book pages it comes from. None of it is dosing advice.
Latest articles
Cognitive
Selank and Semax: Two Peptides From the Other Side of the World, Doing Two Different Jobs
Same research group, same stabilising tail, different targets. What each one reaches for, and where they overlap.
Longevity
Telomeres and Batteries: What Epitalon and NAD+ Are Actually Doing
One is aimed at how cells age, the other at whether they have the energy to function at all. Two different failures.
Metabolic
Losing Weight and Losing Muscle: What the Growth Hormone Axis Has to Do With It
Why rapid loss takes lean mass with it, and how tesamorelin and ipamorelin reach the same axis through different doors.
Metabolic
Your Fat Is Moving. Is Anything Equipped to Finish the Job?
Fat leaving a fat cell is not fat leaving the body. The two gates in between, and what each one runs on.
Repair
The Immune Rules Most Peptide Protocols Ignore
Why BPC-157, TB-500 and GHK-Cu underperform in inflamed tissue, and the four immune rules that fix protocol design.
Repair
Peptide Protocol Sequencing: Why the Order Matters More Than the Stack
Healing runs in phases, and each compound has one where it helps most. Five sequencing principles, explained plainly.
Repair
Why Regenerative Peptides Don’t Work: The Cellular Battery Problem
Repair runs on cellular energy. What happens when mitochondria decline, and what SS-31, MOTS-c, Humanin and NAD+ are meant to address.
Repair
Leaky Gut and Systemic Inflammation: The Peptides That Protect the Gut Lining
How a weakened gut barrier drives inflammation body-wide, how the microbiome shapes immune tolerance, and where BPC-157 and KPV fit.
Metabolic
Metabolism Is an Information System: Retatrutide, GHRH vs GHRP, and the Logic of Stacking
How retatrutide works, the real difference between GHRH and GHRP, and why adding GH peptides too early backfires.
Browse by system
Repair
Immune regulation, sequencing, the gut barrier and cellular energy. Companion articles to Regenerative Resilience.
Metabolic
Metabolism and body composition
Incretins, the growth hormone axis and mitochondrial signalling. Companion articles to Metabolic Precision.
Longevity
Telomeres, mitochondria, NAD+ and the bioregulators. Companion articles to The Longevity Map.
Cognitive
Neurotrophins, the stress response and neuroprotection. Companion articles to The Cognitive Advantage.
Want the whole framework?
The articles are starting points. The books hold the full reasoning, compound profiles and case models.
See the book seriesTry the Protocol BuilderEducational information only, not medical advice. Published by NuTide Paradigm.