The Compound Library
Every compound in the framework, grouped by the system it actually speaks to — what it does, how it is used, and where it sits on the experience curve. No dosing, and no hype.
How to read this library. Compounds are grouped by the system they act on, not alphabetically, because that is how protocols are actually built. The label on each card — foundational, intermediate or advanced — is about how much margin for error it leaves you, not how well it works.
There are no doses here. That is deliberate. An amount without the context of your situation, your experience and the rest of your protocol is worse than no number at all. Dosing ranges live in Targeted Peptide Systems, and belong in a conversation with a qualified clinician.
If you want this turned into an actual protocol for your situation, the Protocol Builder does it free, and explains its reasoning as it goes.
The growth-hormone axis
These work on the body's own growth-hormone release rather than replacing it. GHRH analogs tell the pituitary to release; GHRPs amplify the pulse when it comes. That distinction matters, because one from each family works together, while two from the same family mostly compete.
Ipamorelin
Cleanest GHRP — minimal cortisol/prolactin bleed. Ideal amplifier alongside a GHRH analog. Best beginner GHRP.
Sermorelin
Gentle physiologic GHRH analog. Best entry GH compound. Pairs synergistically with Ipamorelin (different receptor — not redundant).
CJC-1295 (no DAC)
Amplifies pulsatile GH without blunting natural rhythm. Intermediate upgrade. Combine with one GHRP for pulse amplification.
CJC-1295 (w/ DAC)
Long-acting GHRH for sustained GH baseline. One GHRH per cycle — do not combine with CJC no-DAC or Sermorelin.
GHRP-2
Potent GH secretagogue. More cortisol/prolactin than Ipamorelin. Intermediate use. One GHRP per cycle only.
GHRP-6
Strong appetite stimulation + GH pulse. Best for ectomorphs or hardgainers. One GHRP per cycle.
Kisspeptin-10
Upstream LH/FSH stimulator — supports gonadal axis and testosterone recovery.
MK-677 (Ibutamoren)
Oral GH secretagogue — replaces injection-based GHRPs. Sustains GH/IGF-1 continuously. Monitor fasting glucose; avoid in insulin-resistant endomorphs.
Tesamorelin
GHRH analog with visceral fat reduction data. Preferred where GH and metabolic goals overlap, especially in endomorphs.
Hexarelin
Strongest GHRP. Rapid receptor desensitisation — 4 wk on/off mandatory. Advanced only.
IGF-1
Direct anabolic signalling. Advanced only — not a default addition. One IGF compound per cycle maximum.
IGF-1 LR3
Long-acting IGF-1. Greater systemic exposure. One IGF compound per cycle — conflicts with IGF-1.
Metabolic and fat loss
Appetite, blood sugar and fat storage are one connected system, which is why compounds here overlap so heavily. The incretins dominate the category and are the ones most likely to need a clinician's input.
AOD-9604
GH fragment — lipolysis only, no IGF-1 or GH axis interference. Safe adjunct to any GLP-1 stack.
L-Carnitine
Fatty acid transport — addresses poor fatty acid oxidation. Complements any metabolic stack.
Lipo-B
Lipotropic blend. Supports hepatic fat clearance. Pairs well with any GLP-1 driver.
Semaglutide
Entry-level GLP-1 engine. Best for titration-sensitive beginners. Appetite suppression + glucose regulation. One incretin per stack.
5-Amino-1MQ
NNMT inhibitor enhancing fat cell metabolism. Complements GLP-1 via a different pathway — not redundant.
Cagrilintide
Amylin analogue — satiety via a different receptor than GLP-1. Addresses persistent hunger without receptor redundancy.
Tirzepatide
Dual GIP/GLP-1 agonist — superior fat loss and glycemic control vs single GLP-1. Two receptor pathways.
Retatrutide
Triple agonist — maximum metabolic driver. Adds glucagon-driven energy expenditure. Reduces need for additional appetite compounds.
Structural repair
Tendon, ligament, gut lining and muscle. The two workhorses act through genuinely different pathways, which is why they are so often discussed together rather than as alternatives.
BPC-157
Broadest-spectrum regenerative peptide. Angiogenesis, tendon, muscle, gut healing. Foundation of any repair stack.
GHK-Cu
Copper tripeptide driving collagen synthesis and anti-fibrotic remodelling. Matrix remodeling layer.
TB-500
Distinct cytoskeletal pathway from BPC-157 — highly synergistic pairing. TB-500 or TB-4 per cycle.
ARA-290
EPO receptor modulator — neuropathic pain, vascular repair, anti-inflammation. Different receptor from BPC-157.
TB-4 (Thymosin β4)
Parent of TB-500 with greater immune modulation. Use TB-500 OR TB-4 per cycle — partially redundant.
B7-33
Anti-fibrotic. Layer after repair initiation for fibrotic conditions. Investigational — advanced use only.
Neurocognitive
Focus, memory, mood and sleep. The hardest category to self-assess, because the thing doing the assessing is the thing being changed — which is exactly why written checkpoints matter more here.
DSIP
Deepens slow-wave sleep. Pairs with pulsatile GH timing for overnight recovery.
Oxytocin
Social bonding, stress regulation, gut motility. Primary for social dysfunction. Pairs with Selank.
Selank
Anxiolytic modulation. Complements Semax (different MOA) — balances stimulation with calm clarity.
Semax
Foundational cognitive compound — BDNF, attention, focus. AM use only; afternoon dosing disrupts sleep.
Cerebrolysin
Multi-neurotrophic — brain repair, cognitive enhancement, neuroprotection. Clinic-level IV administration.
PE-22-28
Spadin analogue — neuroplasticity, antidepressant signaling, sleep support. Intermediate research compound.
P-021
CNTF-derived neuroprotective peptide. Cognitive preservation. Investigational — advanced only.
Immune and inflammatory
Modulators rather than stimulants, in most cases. The general principle in the framework is to settle an over-reactive system before trying to provoke a sluggish one.
Glutathione
Master antioxidant. Universal adjunct — no known conflicts. Supports redox balance across all systems.
KPV
Alpha-MSH tripeptide. Converts a repair stack into an anti-inflammatory regenerative stack. Synergistic with BPC-157.
Thymosin Alpha-1
Gold-standard immune modulator. T-cell maturation and innate regulation. Modulate before stimulate.
LL-37
Antimicrobial + angiogenic + anti-inflammatory. Complements Thymosin Alpha-1 via a different pathway.
VIP
Vasoactive intestinal peptide — neuroimmune regulation. Specialized: chronic inflammatory or neurocognitive patterns.
Mitochondrial and cellular energy
Upstream of almost everything else. When fatigue is the presenting complaint and the obvious metabolic causes are ruled out, this is where the framework looks next.
NAD+
Universal cellular cofactor. Foundational support across all systems. No conflicts — appropriate at all levels.
Humanin
Mitochondrial-derived peptide. Neuroprotective + metabolic + anti-apoptotic. Synergistic with MOTS-c and SS-31.
MOTS-c
Mitochondrial-derived peptide. Best for metabolic adaptation and insulin sensitivity (AMPK). Synergistic with NAD+.
SS-31 (Elamipretide)
Mitochondrial membrane stabiliser. Best for oxidative stress and tissue recovery (heart, skeletal muscle). Synergistic with NAD+ and MOTS-c.
Longevity
The slowest category to show anything you can feel, and the one where expectations most need managing. Judged on markers over long horizons, not on how a given week went.
Epitalon
Telomere-supporting tetrapeptide. Anti-aging, circadian, immune modulation. Cycled seasonally.
FOXO4-DRI
Senolytic — space clearly from continuous mitochondrial peptides. Advanced only.
Bone
A small category with a narrow, specific job.
Calcitonin
Calcium regulation and bone metabolism. Indicated for bone density concerns or calcium dysregulation.
Blends
Pre-combined formulations. Convenient, but they remove your ability to change one variable at a time — and they can silently duplicate something already in your protocol.
GLOW Blend
All three repair layers in one protocol. Do not add individual blend components alongside.
KLOW Blend
Adds KPV to convert repair stack into anti-inflammatory regenerative stack. Use GLOW or KLOW — not both.
Knowing the compounds is not the same as having a protocol.
Which of these belong together, in what order, and for how long — that is the part the framework exists to answer. Start with the free Builder, or read the book it was built from.